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This mode of interaction differs from a common binding mode for single-domain antibodies and antibody mimics in which recognition loops recognize clefts in targets.
This mode of interaction is consistent with an earlier positional screening study, where little selectivity for proline was observed [9].
This mode of interaction does not involve sequence-specific contacts between DNA segments or specific divalent cation bridges.
The structural basis of this mode of interaction has been investigated in depth and involves both domain 1 and domain 3a of Munc18-1 [9].
This mode of interaction does not necessarily require interaction with the 5′ terminus of the RNA.
This mode of interaction compensates for the energy cost to locally unwind an RNA duplex, which is critical for DEAD-box protein function (Del Campo et al., 2009).
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This study presents the mode of interaction, structural features, and micellization of amphotericin B (AmB) with sodium deoxycholate sulfate (SDCS) as small lipid molecule at different ratios, as revealed by molecular docking simulations and nuclear magnetic resonance (NMR).
In the final stages of this work, we simulated the mode of interaction between Tan IIA and targeted proteins by the virtual docking research platform.
This observation suggests that the mode of interaction between NFκB and other proteins, such as ER, is also target gene dependent, even in the context of a single molecular background.
Green was especially enthusiastic about the mode of interaction used by the canvassers, which other studies have also shown to be effective.
Temperature-mediated expansion alters the mode of interaction of 2D22 binding.
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