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The slight recovery of the steady-state level of mt-tRNAGlu in the face of dramatic clinical improvement indicates that either this mild increase of mt-tRNAGlu steady-state level is sufficient to regain normal mitochondrial translation, or that other mechanisms downstream of mt-tRNAGlu explain the clinical and biochemical improvement in vivo.
The slight recovery of the steady-state level of mt-tRNAGlu in the face of dramatic clinical improvement indicates that, either this mild increase is sufficient to regain normal mitochondrial translation or other mechanisms downstream of mt-tRNAGlu are responsible for the clinical and biochemical recovery.
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And that mild increase has been largely driven by just one state.
This relatively mild increase in cholesterol levels was also observed in late endosomes from cells of NPC patients [28].
This was associated with mild increase in transaminases (AST 56 IU/L, ALT 60 IU/L).
This suggests that a mild increase in ROS in IPC kidneys confers resistance to subsequent I/R insults.
This was accompanied by a mild increase in proliferation (Fig 3G).
This drop is measured as a mild increase in τ c.
This excessive collagen production was accompanied by a mild increase in the number of SMCs in the media of large arteries (Fig. 3, graph).
In another patient, a mild increase in creatinine levels was recorded and this brought to decrease the daily dose of the drug from 500 to 250 mg.
This observation suggests that Gpa33 −/− mice exhibit a mild increase in luminal antigen flux into the colonic LP.
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