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It appears that HA synthase HAS-3 plays a major role in this mechanisms because transplantation of stem cells to mice lacking this synthase (Has-3−/−) leads to aberrant distribution of the grafted cells in bone marrow compared to the wild type recipients [ 58].
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Moreover, the lack of HD links with high nN in the yeast PIN (Figure 3A) would also be explained with this mechanism, because HD links with high nN should be rare if the duplicability of high-degree nodes is low.
The fact that curvature can have opposite signs in different subjects is consistent with this mechanism because the optimization process will follow a different path in every individual, due to the different realizations of motor and sensory noise in the saccades made during the optimization process.
Checkpoint controls are implicated in this mechanism because inhibition of Chk1 and Chk2 checkpoint kinases remove the resistance to radiotherapy.
Radical-clock hydantoins bolstered this mechanism because the hydroxylation event occurs faster than the rate of cyclopropyl radical ring opening.
The reason why maternal smoking status modified the association between proximity and term LBW may also be related to this mechanism, because smoking is associated with placental insufficiency during pregnancy [ 41].
Genetic epistasis analysis suggests that OMA-1/ 2 may be part of this mechanism because oocytes do not undergo meiotic maturation in lin-41 (tn1487 ts ); oma-1 (zu405te33); oma-2 (triple triple mutants (Table 2).
NR was a candidate protein for this mechanism because Met, located at the P+4 position, serves as a hydrophobic recognition element for phosphorylation of Ser and its oxidation substantially inhibits phosphorylation of Ser in vitro.
In addition, although the study was based on the hypothesis that phthalates cause metabolic abnormalities by decreasing androgen levels or function, the authors couldn't examine this mechanism, because the NHANES data do not contain measures of sex hormones in men.
This mechanism functioned because economic relations have been embedded into social relations (Polanyi 2013; Granovetter 2008).
The propagation of the PI from high to low latitudes is often interpreted as an instantaneous transmission of atmospheric THo mode along the ionosphere ground waveguide (Kikuchi and Hashimoto 2016), though some researchers (e.g., Yumoto et al. 1997; Chi et al. 2001) consider this mechanism questionable because of the observed finite time delay between the PI detected at separated sites.
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