Because SDF-1-CXCR4 system is also active in B cells to activate and to migrate [ 47], in osteoclasts to produce MMP-9 [ 48], in chondrocytes to produce MMP-3 [ 49], in endothelium to induce angiogenesis [ 50], and in Th1 cells to migrate into synovial tissues [ 35], this system may play very important roles in a multiple ways in the development of RA.
Although miR-34 family was discovered early in miRNA biology as the major component of the p53 tumour suppressor network, we only recently have begun to decipher its physiological function, and it may play very different roles in different tissues [24, 40], including osteoclastogenenesis, ciliogenesis, or cardiac aging.
Such finding, which is further illustrated in co-localization experiments (Figure S3), implies that these transcripts may play very different roles despite having similar regulatory processes.
These results suggest that different allelic genes may play very different roles during different growth phases in the fermentation.
Members from PIN1-3 groups and GmPIN9d may play very important roles in soybean root development due to their relatively strong expression in this tissue.
Their combined coefficient was greater than any other gene, indicating that these genes may play very important roles in the toxicity.
In this study, the duration of thyroid dysfunction suggests that physiological compensatory and pathological hypertrophy may coexist and lead to a concentric cardiac hypertrophy, in which thyroid hormones may play very different roles from those in eccentric cardiac hypertrophy [ 13].
It was well established that various proinflammatory cytokines may play very crucial roles in the development of pancreatitis, which may accelerate the deterioration of pancreatitis into systemic inflammatory response syndrome and may result in organ failure or even death [ 41].
Homologues of SnRKs occur in all kingdoms and they appear to be highly conserved among yeasts, animals and plants suggesting that they may play very similar roles across species [ 35].
As summarized in previous paragraphs, significant evidence indicates that NC-RNAs with different length may play very similar cellular functions, thereby suggesting the need for a classification system based not on transcript size but on molecular function.
