This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding sites, the enhancement of traditional virtual-screening methodologies, and the direct prediction of small-molecule binding energies.
In this respect, many roles for PKD2 have been described [ 33].
This has uncovered many roles in diverse developmental and physiological processes.
This domain has many roles including involvement in MutL protein and DNA binding activity and activation of the endonuclease MutH.
This central character plays many roles: a destination to be attained by days or weeks of travel, a place to meet new people and experience other ways of life, and an enemy of creature comfort, health and hygiene, and life and limb.
But for now, it might be best to stay away from the CO2, so you can play many roles after this one.
Apart from this role in cuticle formation, many roles were proposed for LTPs including systemic resistance signaling [ 51], ability to promote cell wall expansion through binding to a hydrophobic partner in cell walls [ 52], and activation of a PG [ 53].
But this was just one of Schiller's many roles.
A woman of many names, this German, Austrian, Swiss, and Alsatian spirit fulfills many roles.
The city plays many roles.
Crustaceans play many roles in aquatic ecosystems.
