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For detailed information regarding programming the clinical decision support described in this manuscript, please contact the corresponding author.

For inquiries regarding data supporting the findings presented in this manuscript, please contact the corresponding author, Dr. Marcus Law, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King's College Circle, Room 3157, Toronto, ON M5S 1A8 Canada Tell: 416-978-4543; Email: [email protected]@utoronto.ca

We now clarify this in the manuscript (please see the Introduction and the subsections entitled "Post-diagnostic interventions" and "Prevention vs. post-diagnostic intervention").

We discussed this point in the manuscript (please see the subsection "Lung monocyte-derived cells are located at the interface between blood and airways" and the Discussion).

The points summarized here are now extensively discussed in the manuscript (please see the Discussion section).

The discussion above has been incorporated in the manuscript (please see the fourth paragraph of the Results and Discussion section).

The discussion above has been incorporated in the manuscript (please see the third paragraph of the Results and Discussion section).

We briefly discuss it in the manuscript (please see the Discussion section and the legend for Figure 2 figure supplement 1).

Summarizing, the given results and observations, from the herein conducted expression analyses, agree with what we describe in the manuscript (please see attached manuscript for details).

We follow the RATS guideline for qualitative component of the manuscript (please see the RATS checklist provided as an Additional file 1).

4) In the Discussion section of the manuscript, please consider that the limits in the interpretation of the experiments need to be acknowledged.