Exact(3)
We gratefully acknowledge the helpful contributions from reviewers of this manuscript, namely Wendy Snowdon and Colin Bell.
A separate issue relates to new data on the Mississippi baby that was announced subsequent to the submission of this manuscript, namely the baby has detectable virus and this manuscript needs to be updated accordingly.
In the first expanded dataset we increased the taxonomic sampling of microsporidians by adding genes from three recently released microsporidian genomes, which only became available during the preparation of this manuscript: namely Octosporea bayeri, Encephalitozoon hellem, and Vavraia culicis [ 39, 40], and one additional Zygomycete: Mortierella verticillata.
Similar(57)
This point has prompted an additional clarification in the manuscript, namely that not every activating hypnozoite will correspond to a relapse.
Of the four polymer combinations containing beads those that possessed the highest entrapment efficiencies are described and evaluated in detail in the manuscript namely; F5, F6, F7 and F8.
Relatively few proteins will bind to chromatin alone, as the author acknowledges later in the manuscript, namely the subunit of a complex will immunoprecipitate with the other proteins of the same complex.
We also note that we have downplayed the second major discovery contained in the previous version of the manuscript, namely the clear biochemical identification of a fully functional and unanticipated IPK activity in all domains of life with a particular emphasis on the green plant lineage.
I think that the main result of the manuscript namely "a simple and general mechanistic model of HIV interaction with antiretroviral drugs that that takes into account the kinetics of the HIV viral life cycle" is very interesting and a valuable contribution.
To address this comment we have added four new figures or supplemental figures to the revised manuscript, namely Figure 5, Figure 5 figure supplement 1, Supplementary files 1 and 2, Figure 8.
And that is the main thrust of the present manuscript, namely, to present a quantitative way to relate network topology with information in active networks.
We believe that our revised manuscript addresses the main overall critique of our original manuscript – namely that we had not identified a physiological condition under which σ trans loading could be expected to have a significant effect on transcription in the cell.
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