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The secondary analysis described in this manuscript identified characteristics of APS that may correlate with improved Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and Outcome Measures in Rheumatology-Osteoarthritis Research Society International (OMERACT-OARSI) responder status after treatment with an intra-articular injection of the APS.

Reviewer #1: This manuscript identified a new motif, SADH, in the C-terminal region of Scribble.

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The studies presented in this manuscript identify TIEG1 as a novel and important regulator of Runx2 expression and activity.

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Reviewer #3: This manuscript identifies the ontological source of an important bone marrow (BM) niche cells previously identified by the senior author.

This manuscript identifies a novel mechanism of human tumor-mediated immune suppression and provides a new strategy using TLR8 ligands to reverse tumor immunosuppressive effects for tumor immunotherapy.

This manuscript identifies a putative C. elegans ortholog of ninein (called NOCA-1), characterizes its in vivo functional roles and its microtubule binding properties and demonstrates genetic interactions with the minus-end binding protein Ptrn-1/Patronin.

In addition, the manuscript identifies a pocket at a dimer interface between head domains that can be targeted by small molecules.

The manuscript identified a novel mechanism by which BRCA1 is regulated by the ubiquitin-dependent degradation in response to ionization.

This would approximate the typical literature search performed by many researchers in North America, and accordingly all the manuscripts identified by the PubMed MEDLINE search were readily available in local university libraries.

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