Eugene V. Koonin, National Center for Biotechnology Information, NIH, USA This very brief manuscript defines and solves an important problem in the theory of evolution.
In the manuscript defining our methodology, we described near-miss events as events which occur but do not reach the patient, through either chance or by active recovery.
By applying the p-adic q-integral equation to continuously differentiable functions on ring of p-adic integers, in this manuscript we define generating functions for new family of special numbers and polynomials.
The 0 h timepoint described throughout this manuscript is defined as the end of the transfection procedure (i.e., 24 h after transfection was initiated).
In this manuscript, we define the essential components of this infrastructure, explain why each component is needed, and provide recommendations for establishing this infrastructure.
Severe malaria in this manuscript is defined based on WHO definition of severe malaria [ 17] which includes the criteria of hyperparasitemia.
The main exposure of interest was local spread, which in this manuscript was defined as the unidentified mechanism of PCVAD spread from infectious to susceptible premises located within 3 km of the Euclidean distance.
For the purposes of this manuscript, we define it in counterfactual terms: "Had the exposure differed, the outcome would have differed", where exposure or outcome may be dichotomous (e.g. presence/absence of exposure; occurrence/disappearance of disease) or continuous (e.g. a different value of blood pressure whether blood pressure is exposure or outcome).
Remission was a priori defined as a MADRS total score ≤12 (called partial remission in this manuscript), and was defined post hoc as a MADRS total score ≤8 (as recommended by the International Society of Bipolar Disorder [ISBD], called full remission in this manuscript) [ 19].
Fig. 5 Features of orthosis in this manuscript and its defining method for immobilization area.
While not a focus of this manuscript, we also defined developmental links: edges connecting genes co-expressed synchronously in the course of development (exemplified at Fig. 3A; see Methods S1 for details of the calculation).
