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Exact(1)

PI3Kα inhibitor IV ("p110αi" in this manuscript, corresponds to figure 15e in ref (27)), TGX-221, Akt 1/2 inhibitor VIII ("Akti"), and U0126 were purchased from Calbiochem (San Diego, CA).

Similar(58)

Genetic plasticity, as described on the manuscript, corresponds to the gene (or gene network) capacity to tolerate changes and the evolutionary plasticity, defined by Eq.1, is the record of changes a given gene family have experienced through its evolutionary history.

The average size indicated in the manuscript correspond to the size of a sphere, and we clarified this point in the text.

To me, 'digestion of neighboring cells', 'extracellular digestion and diffuse nutrient uptake' (referred to as predation in the manuscript) correspond to osmotrophy and, as such, are common to both prokaryotic and eukaryotic organisms.

All fat body images in the manuscript correspond to mid-to-late third larval instar fat body dissected prior to the wandering larva stage, except for the first and second larval instar images in Figure 3 figure supplement 1A and sec23 i second instar larvae in Figure 5 figure supplement 1B.

Throughout this manuscript, stage corresponds to disease stage at initial diagnosis.

Sequences for the L. fluviatilis and P. marinus sequences analyzed in this manuscript have been submitted to Genbank and correspond to accession numbers FP243278 to FP243359.

This manuscript is derived from the thesis of the Corresponding Author, SH.

You have guarded this manuscript very closely.

Conclusions concluded this manuscript.

Throughout this manuscript.

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