Sentence examples for this loss of responsiveness from inspiring English sources
The cellular and molecular mechanisms underlying this loss of responsiveness are not clear.
In order to determine if this loss of responsiveness to FSH was due to an inability to stimulate adenylyl cyclase, the hormonal responsiveness of this enzyme was investigated as a function of testicular development.
These findings indicate that N-linked oligosaccharides are required for holo-Tf-induced stabilization of hTfR2 and that no single N-linked site is responsible for the loss of responsiveness to Tf.
Clinical evidence shows that motor-evoked potentials, and thus motor function from cortex down, remain intact in this state, making it unlikely that the loss of responsiveness we observed is only a result of disrupted motor function (Moore et al., 2006; Garavaglia et al., 2014).
Maintenance of tissue homeostasis is a tightly regulated process and the loss of responsiveness to negative growth signals can alter this delicate balance, leading to cancer [1].
Despite this, it was not possible to determine whether IgG or IgM Ab mediated the loss of responsiveness.
Our results demonstrate that the loss of responsiveness to TGF-beta-induced growth inhibition correlates with the loss of expression of DPC4.
The majority of TCDD effects are mediated via binding and activation of the intracellular aryl hydrocarbon receptor (AhR), as demonstrated by the loss of responsiveness to TCDD in AhR knockout mice [5].
To eliminate possible involvement of ASE neurons in the loss of responsiveness by ceh-36 mutants, we also tested a che-1 line, which is defective in the specification of ASE [25].
Interestingly, the loss of responsiveness to some cytokines was initially non-uniform: at 10 weeks of age the Stat1 response to IL-6 was ablated in roughly half of CD4+ T cells while it was high in the other half (Fig. 2B).
Our understanding, therefore, of the acquisition of hormone responsiveness in the normal breast and the loss of responsiveness in advanced breast cancer is critical to developing therapeutics to treat this disease.
