Sentence examples for this loss of function from inspiring English sources

Thus this loss of function mutation that co-expresses altered circadian phases and migraine with aura indirectly highlight a potential relationship between PER2 regulation and migraine.

This loss of function, assessed as the primary endpoint, was prevented for two years in olesoxime-treated patients, with fewer disease-related adverse events.

This loss of function may relate to the level of interact between SERT and cytoskeleton network.

This loss of function was temporary, since full DOR-eGFP receptor responses were restored 24 hours after SNC80 administration.

Interestingly, this loss of function is rather recent in the course of evolution, as Xenopus MBD3 does bind methylated DNA, whereas mammalian MBD3 does not [33].

Given that the amino acid responsible for this loss of function is highly conserved over a broad range of bacterial species, we speculate that homologous mutations in other bacterial species would also result in a loss of AI-2 phenotype.

The glycine residue responsible for this loss-of function mutation (G113C) is conserved in all known TGMs and lies close to the catalytic domain of the enzyme [62].

This loss-of-function effect was confirmed by measuring the secretion of endogenous mediators in supernatants of HEK 293T cells (n = 3, p<0.0001; Fig. 4C).

The development of mouse models of FXS has facilitated cellular studies on the underlying molecular basis of this loss-of-function disorder [10], [11].

If such a substitution sufficiently impairs the AR DNA interaction [33], this loss-of-function mutation might explain the apparent lack of AR responsiveness observed in E006AA cells.

This loss-of-function study further supports the notion that dGIPC has no role, or at best a redundant role, in wing hair patterning and PCP generation.