According to standard nomenclature, this locus is called Hfib1 (hepatic fibrogenic gene 1).
Unfortunately, this locus is located in a low-expression region where none of the genes nearby shows reliable transcripts measurements after quality control (see Materials & Methods).
This locus is responsible for 3.6% of population variance in young adults and 2.5% of population variance in children.
These data suggest that dark induction of this locus is due to increased accumulation of Os01g14100.1 and -.2.
Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability.
We conclude that C4 is an allele of the L5 locus and that this locus is most probably a structural gene for a subunit of RNA polymerase II.
This locus is called a branch cut.
This locus is known to assure stable expression of inserted genes in all cell types [15].
Such low evolutionary rate at this locus is incompatible with current knowledge of gene evolution.
This locus is significant in all the three families, and explains 53.84% of the phenotypic variance.
In E. coli MG1655 a portion of this locus is missing due to site-specific recombination between agaW and agaA [42], however this locus is present and intact in EAEC 042 (Fig. S8).
