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We chose to further analyse this loci with F3 and F4 descendants because no other loci were identified with a strong confidence in the CSSL population.
This may explain why this loci was not identified in our screening approach.
Genes encoding for streptin production are also present at this loci in the two serotype M1 and the M28 genome sequences.
Variations within this loci were predominantly found in smokers and correlated with smoking-related lung cancer as well as other diseases like peripheral arterial disease [61].
However, due the complex nature of the 9p21 loci containing also the p14ARF and p15INK4b tumor supressors, it is difficult to score the true relevance of p16 in this loci loss.
For STAT5A, we confirmed the significantly greater extent of methylation at the specific CpG site measured by the array, but did not observe this association in the neighboring CpG sites (Fig S2B), and so this loci was not further investigated.
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This locus also harbors multiple variants associated with a range of other cancers.
A second component of this locus contains a smRNA signal immediately adjoining a GWAS hit.
. "Madagascar has been suffering for years from this locus pest and the problem is only growing.
However, little is known about the mechanisms that govern the expression of this locus.
The answer will only be found by further genetic analysis of this locus in Africans.
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