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This literature makes clear the importance of introducing firm heterogeneity and quality differentiation in models of exports.

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This literature, made up of opinion articles, editorials and single participant experiences, present an array of insightful suggestions and recommendations for actions that hospital managers should take to improve the quality of patient care delivery in their organisation.

The introduction of a new consensus nomenclature (Schweizer et al. 2006), which for the common (non-hair follicle specific) epithelial keratins widely conserves the older names established in the literature, makes this complex field much clearer than before and will facilitate future research.

We also agree that the heterogeneity in the literature makes comparisons difficult and indeed it is for this reason we did not attempt a meta-analysis.

The extreme variability of experimental methods used in the literature makes it difficult to compare results between friction studies.

However, numerous models presented in the literature makes selection of the best, proper predictive model a cumbersome task.

To our knowledge the literature makes no reference as to the definition of success in material distribution.

This extensive literature makes clear that the genetic basis for pigmentation changes is complex, with prominent pleiotropic and epistatic effects (cf. Reissman and Ludwig 2013).

This extensive literature makes it clear that both mTOR complexes impact processes of cell differentiation in several cell types, and that an important component of this in some cells includes regulating cholesterol and lipid synthetic pathways.

In fact, ∼60% (15/24) TP were annotated from the literature, making this benchmark evaluation moderately biased in favour of ELM.

Yet, our unpublished observations of patients with refractory gallbladder cancer who responded to erlotinib plus chemotherapy and the rarity of complete responses to chemotherapy reported in the literature make this seem unlikely.

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