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To that end, we compared genomic profiles from 22 tumours taken from individuals with known arsenic exposure in Northern Chile (12 smokers, 10 never smokers) against profiles from 30 lung SqCCs obtained from North America (none of this latter panel had any documented exposure to arsenic).
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Participants for the latter panel were the hardest to recruit despite initial invitations to a large number of organisations.
Interestingly, HIF-1 α was expressed to a higher level in HEK293-P2X7 than in HEK293-mock cells, and reduced glucose enhanced its expression in the former but not in the latter (panel d).
However, comparisons between the BAC map, the 12 K BTA14 RH map and the assembly showed that the highest agreement is between the BAC map and the RH map (Warren Snelling, personal communication), with the latter panel being constructed from an Angus bull (JEW38) fibroblast cells [ 8].
We verified this prediction by analyzing the ImmPort list which contains 2,287 genes involved in immune response and covered in the HGDP-CEPH panel, this latter containing data for more than 660,000 single nucleotide polymorphisms genotyped in almost 950 individuals sampled throughout the world (Additional file 1, Table S1) [ 11].
Since hit SNPs make up a small fraction of all SNPs, we shall use the annotation proportion seen in unselected GWAS panel sets for this latter quantity.
This latter point is vital.
This latter seems familiar enough.
This latter point is crucial.
This latter statement was chilling.
This latter combination was no coincidence.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com