The genetic region encoding amino acids defining this pocket is largely conserved within the different alleles studied, presenting just a single dimorphic variation in the Gβ86V position among human HLA-DRβ1* molecules.
This process is largely conserved from yeast to human.
In the metagenomic sequence, this context is largely conserved.
Sex-chromosome-linked components of this signature are largely conserved throughout pre-implantation development and in ES cells, whilst the autosomal component is more dynamic.
This gene context is largely conserved within Enterobacteriaceae; e however, outside this taxonomic group, the gene context is highly varied, and numerous examples can be found where YdiI and the menaquinone pathway genes are colocated (see Figure 2 and Figures SI2 and SI4 of the Supporting Information).
Therefore, we can speculate that this gene family is largely conserved during the evolutionary process.
The results demonstrated that EST approach was successful in uncovering homologues of many (90 or more) putative floral regulatory genes, supporting the hypothesis that this regulatory pathway is largely conserved in angiosperms.
Second, after performing a sequence homology search using CLUSTALW (http://clustalw.ddbj.nig.ac.jp/top-j.html), it was determined that this base pairing is largely conserved in other species as C G or adenine thymine base pairings (Fig. 5c).
Changing this residue, which is largely conserved in the K2P family as a small sidechain (Supplementary Figure S2), to a larger residue that is found in members of the TASK K2P subfamily, G137I, stabilizes a potassium-selective conformation of the selectivity filter (Supplementary Figure S3) and renders K2P2.1 (TREK-1) irresponsive to both extracellular and intracellular gating commands.
As shown in Fig. 1, gene order and telomere location are largely conserved at this scale, although the number of chromosomes is quite variable across species.
