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It is thus not surprising that lead's toxicity is not specific to the brain and we do not believe this lack of target organ specificity diminishes the inference for a causal relationship between lead and cognitive dysfunction.
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This lack of targeting could have been related to antigen heterogeneity and low expression of GPC3.
Our earlier results indicated that Py17X infection induces a strong, cytotoxic CD8 response against SQLLNAKYL (Fig 5), but the lack of target cells presenting this epitope in the brain microvasculature could explain the absence of ECM.
However, the image intensity-based trackers can hardly handle the complicated situation in practical visual tracking due to the lack of target structural information.
The classification performance did not fall during adoption of the transfer learning algorithm, which effectively avoids the classification performance degradation or even failure under the lack of target data samples and the traditional lower layer visualizing feature extraction algorithm.
A differentiation must be made between results achieved due to the lack of target nucleic acid (true negatives) and those produced due to the inability to amplify target DNA (false negatives) so confidence in negative reactions is possible.
It is thus likely PTEN ablation preserves DA neurons that normally would undergo apoptosis due to the lack of target support, by repressing the initiation of apoptotic pathways.
However, the role of miR-320b in CRC is not fully understood because of the lack of target gene information.
These inhibitors reportedly produce side effects in clinical settings primarily due to the lack of target specificity and/or selectivity.
Disadvantages include the lack of target cell specificity, potential of immunogenicity, and our incomplete knowledge of the molecular mechanisms of protein transduction.
This could be due to the use of a small number of transducers and the lack of target scattering contribution to the PAT reconstruction through the optical fluence/photon density.
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CEO of Professional Science Editing for Scientists @ prosciediting.com