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This lack of domain expertise may put patient safety at risk and make these workflow platforms difficult to operationalize in a clinical setting.
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Such work was not yet carried out, due to the lack of domain specialists.
Annotator C followed the instruction much better than the other two (although there are some consistent errors due to the lack of domain knowledge) and annotated almost all building elements shown by the BIM overlays.
Instead, it is likely that the lack of Domain 2 to 5 affects other essential functions of Noc4p.
This simple feature, which is based on normalized counts of single or pairs of amino acids, is applicable to proteins from any sequenced organism and can be used to compensate for the lack of domain information.
Thus, despite the lack of domain 1, RFH could be a fully active class-I RF, capable of promoting peptidyl-tRNA hydrolysis and polypeptide chain release.
RFH resembles the shape of a tRNA molecule more closely than RF1 or RF2 (Fig. 1C), mostly due to the lack of domain 1.
This still is a nightmare due to the lack of domain-specific adaptable tool and data integration solutions which support maintenance of traceability links, semi-automatic consistency checking as well as update propagation.
These challenges are exacerbated by the lack of domain-specific methodological research in library and information science (LIS) that addresses the developmental needs and attributes of young people.
The large molecular weight (∼150 kDa) of whole antibodies results in slow accumulation in target tissue, while the lack of domains that mediate clearance and excretion leads to slow blood clearance.
Given the fact that sAPP β also carries the E1 domain, this lack of neuroprotective properties of sAPP β versus sAPP α is currently difficult to understand, but may involve conformational differences between these two molecules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com