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This kind of mutations, therefore, represent the most common cause of familial CPP.
However, as indicated before, we mainly screened patients living in North-West Belgium; in other regions, this kind of mutations may be more prevalent.
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Virtually every variety of wheat and barley you see growing in the field was produced by this kind of "mutation breeding".
Thus, this kind of mutation has arisen several times independently.
In Senegal this kind of mutation can be detected in 67% of HCC patient [ 32].
However, we already know that this kind of mutation is nonrandom because of the biological marking of the cytosine, which causes the mutation one way or the other.
This kind of mutation is associated with a defective suppression of the alternative complement pathway activation and it is clearly involved in the pathogenesis of aHUS.
Thus, our finding also indicates that this kind of mutation in S. pyogenes 23S rRNA genes can arise in a clinical situation.
This kind of mutation can effectively compensate for fitness decay from Muller's ratchet [ 62] and might be based on variability in quantitative trait loci (QTL) that are not mechanistically related to the mutational damage that they compensate for.
This kind of mutation cuts through the hypercycle, in effect changing it to a linear series of catalytic help with the selfish sequence as the terminal beneficiary, which results in the victory of the parasite and the fatal loss of information thereof.
This is sci-fi stuff: flies with legs growing out of their eyes, the kind of mutations that in any other animal would elicit our horrified response, yet which, because they occur in such small creatures, seem almost excusable because almost invisible.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com