In the case of epilancin 15X, a lanthipeptide produced by Staphylococcus epidermidis 15X154 that is remarkably potent against antibiotic-resistant strains of S. aureus and Enterococcus faecalis, leader peptide removal exposes an N-terminal Dha on the post-translationally modified core peptide.
The molecule RIF-1 is remarkably potent; choanos detect and respond to it at densities that are about one billionth that of the lowest concentration of sugar that humans can taste in water.
The compound is remarkably potent, hitting its unknown target(s) when applied to cells at a submicromolar concentration.
In test-tube experiments, the compounds were remarkably potent in preventing the virus from multiplying, and studies on rodents suggested that they were relatively safe; the only known side effect was liver damage, and then only at very high doses.
Vincent focuses on two pivotal events, World War II and the desegregation of baseball in 1947; the stories of players' wartime efforts and the comments by Larry Doby (1923-2003), who broke the American League's color barrier 11 weeks after Jackie Robinson joined the Brooklyn Dodgers, are remarkably potent.
Synthetic analogs of A-33853 (40) were subsequently found to be remarkably potent against L. donovani axenic amastigotes with compound 41 demonstrating an EC50 value of 0.31 μM and SI value of 99.
Although primarily an NEP inhibitor, SOL1, a more recent combined NEP/ECE non-peptide inhibitor with modest inhibition of ECE-1 in vitro, was remarkably potent in vivo, fully blocking the big ET 1-induced risET 1-induced dose of 10 μmol·kg−1 (Nelissen et al., 2012).
This is remarkably similar to our observations in the current report and it presumably reflects the fact that small changes in these potent transcriptional regulators can have large downstream effects.
This is remarkably short by astronomical standards.
Fortunately, doing this is remarkably easy.
This is remarkably accommodating of the Australians.
