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Q: Yes; but you are not burning electric light during the time this is operative, as you have just told one of the members of this committee.
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The range of concentration over which this effect is operative (0.05 0.20 mol kg−1) overlaps with the range recommended for optimum performance of the lithium anode.
These results suggest that, in addition to their roles in G protein-coupled receptor signaling, beta-arrestins couple the IGF-1 receptor tyrosine kinase to the phosphatidylinositol 3-kinase system and suggest that this mechanism is operative independently of the tyrosine kinase activity of the receptor.
These observations suggest this model is operative in these diseases.
Although it has still to be proven that this mechanism is operative in B cells, it suggests that the partition of TLR4 between different interacting partners might play a role in modulating the B-cell response to LPS.
If this mechanism is operative in the case of spontaneous tumours, genes bearing mutations are likely to be observed not only in the tumours but also in nearby cells showing a histologically and functionally normal phenotype.
This pathway is operative in the heart.
The analysis of 175 tumours showed that ERα/Src, ERα/PI3K and mERα expression is correlated with Akt activation suggesting strongly that this pathway is operative in vivo.
We examined whether this system is operative in multiple myeloma (MM) cells and whether glycolysis inhibition is a potential therapeutic modality.
However, it remains unclear, if this T3SS is operative because of the incompleteness in comparison to the SPI-1 and the replaced genes.
A mechanism for control of the ubiquitin ligase activity of Fbxw7 has been described (Min et al, 2012), but it also remains to be determined whether this mechanism is operative in stem cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com