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This IS element is related to those of the IS21 family and its two isoforms (ISYen2A/B) are present in seven genomic copies in O 3/4.
This IS element was present in all the E. faecium isolates and was also significantly more frequent in E. faecalis ST6 than ST40 strains (p = 0.025) (Additional file 3: Figure S2B and Additional file 5: Figure S3B).
In addition, the transposable element IS605/200 family, as well as degenerate forms of this IS element, are prevalent.
Four members of this IS element with identical nucleotide sequences were present only in the 'Kazusa' substrain, whereas they were absent in the genomes of other substrains.
The rapid mobilization of IS could be limited to the particular element ISY 203, but we do not know the actual trigger of activation of this IS element.
This IS element avoidance hypothesis can explain patterns seen in the GC-rich genomes of Hfx.
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