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Even though gene copy numbers can vary and epigenetic factors may differ to a degree between monozygotic-twins, especially as the individuals age [89], [90], in general, any monozygotic-twin of an MS proband will be genetically susceptible if this is conferred solely by nuclear genes inherited at conception.
We have identified significant differences in the ability of each molecule to inhibit and stabilize GALC and dissected the role of specific chemical groups in order to determine the mechanisms by which this is conferred.
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Further information is required to ascertain whether this is conferring a mortality benefit for these women.
Sreewongchai et al. (2010) found that IR64 has broad resistance to blast disease in Thailand and this was conferred mainly by QTLs on chromosomes 2 and 12.
In mammalian based expression systems, much of this diversity is conferred through heterogeneous protein glycosylation.
We engineered mutants of the human FKBP12 protein that are rapidly and constitutively degraded when expressed in mammalian cells, and this instability is conferred to other proteins fused to these destabilizing domains.
This property is conferred by the activity of Notch through its target gene cut.
This protection is conferred by directing the immune response towards Th2 activation and Th1 suppression.
Mechanistically, this regulation is conferred by direct binding of cGMP to the CNBD, which is allosterically coupled to the HCN channel activation gate.
This specificity is conferred by the substrate through a docking domain.
The authors hypothesize that this resistance is conferred by an escape from G1 cell cycle arrest.
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