Sentence examples for this is a severe problem from inspiring English sources

"The structure of the system militates against young doctors going into clinical research and this is a severe problem for both them and the country," he says.

For evidence synthesis this is a severe problem, because when biases follow more complex patterns and differ for initial studies and subsequent ones, it is particularly difficult to correct for them.

This is a severe problem in China.

In most high-throughput assays, this is a severe problem since there is no means for correcting for differences in enzyme concentration.

At the NVI this was a severe problem when D. nodosus diagnostics were first implemented there.

"The high rate of malaria in this country is a severe problem, and using long-lasting, insecticide-treated nets is one of the best, most cost-effective ways for families to protect themselves from the disease," said Tanya Chapuisat, Country Representative for UNICEF in CAR.

This in itself is a severe problem for the GOP, especially as the West is actually a faster-growing region, but other demographic data from exit polling should be even scarier for party leaders.

This double standard is a severe problem with the traditional view of adaptive evolution.

With respect to waste degradation, this potential lack of robustness is a severe problem, as a population of synthetic organisms would need to be sustained to be effective.

This example shows that there is a severe problem of lack of quantification of the amount of chance that we call upon, not to mention such facts as that the Poldi de novo gene arose already with an alternative splicing pattern [ 11].

and "This example shows that there is a severe problem of lack of quantification of the amount of random chance that we call upon, not to mention such facts as that the Poldi de novo gene arose with an existing alternative splicing pattern [ 11]." This is no surprise, as a novel gene is not expected to arise with perfect splice sites; hence alternative splicing patterns are common.