The ICU environment is a challenging setting in which to conduct research, due to patient heterogeneity, severity of illness, and mortality.
It is important to note that this was a challenging assay to set up because we could not use more extensive methods of amine-based labeling that would have resulted in brighter toxin – such methods are known to interfere with the oligomerization and extensive C-terminal conformational change that is required for SLO pore formation.
Analysts at Credit Suisse said: "Overall, this is a solid set of results given the challenging environment, with a better performance compared to some of the peers".
Delivering comprehensive asthma care to under-served populations is a challenging task in the setting of a brief, problem-focused primary care office visit.
Validating associations in the predicted set is a challenging task (see the Discussion).
However, extracting meaningful results from massive experimental data sets is a challenging task for biologists.
As a high dimensional problem, analysis of microarray data sets is a challenging task, where many weakly relevant or redundant features affect overall performance of classifiers.
At a news conference Thursday alongside the auto workers' president, Rick Wagoner, G.M.'s chairman, said the settlement would "enable us to work together effectively to address what I think is pretty clearly a challenging set of competitors".
Rick Wagoner, the chairman and chief executive of G.M., said the agreement "will enable us to work together effectively to address what is pretty clearly a challenging set of competitors".
"And then, financially, we need to get the right systems and structures in place with the right people with the right skills to make sure we maximise the opportunity in what is a very challenging set of economic circumstances".
