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We have reported that recombinant T. thermophilus MutS2 interacts with MutL, although the biological significance of this interaction remains unknown [31].
So once two interacting partners are identified, the biological relevance of this interaction remains to be determined.
Although originally identified as a Bcl-2 interacting protein (Takayama et al, 1995) the significance of this interaction remains unclear and at present data showing a role for Bcl-2 modulation in BAG-1-mediated survival are lacking.
It is evident that PCBs and MeHg can interact in complex ways to cause functional changes, but the nature of this interaction remains unresolved.
Understanding how engineered nanoparticles (ENPs) interact with natural organic acids is important to ecological risk assessment of ENPs, but this interaction remains poorly studied.
APP-BP1 has been reported to interact with the intracellular C-terminal domain of APP [4], however, the physiological significance of this interaction remains unclear.
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The biological significance of this interactions remains to be further investigated.
Again, however, the molecular mechanism of the interaction remains unclear.
However, the nature of the interaction remains unclear.
Results from in vitro study indicate that erythromycin affects voriconazole metabolism [ 10], although the clinic relevance of this drug interaction remains to be explored.
Coexposure to MeHg appeared to attenuate the PCB-related deficits, but the mechanism for this unexpected interaction remains to be determined.
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