Each indication requires a different dosing and frequency of denosumab administration.
The notion that fluoroquinolone therapy can be "targeted" for an indication requires challenge as fluoroquinolone therapy will always result in systemic drug levels.
Using CAM for those indications requires that long term studies be performed [ 96].
All these injuries fall under the same indication requiring syndesmotic fixation [21].
An estimated 75% of patients with CIEDs will have an indication requiring MRI during their lifetime [ 2].
Several of these indications require the administration of CT contrast agents for enhancement of the vascular system and better differentiation of parenchymal tissue uptake.
Subjects who had an exacerbation or another indication requiring administration of an antibiotic were discontinued from the study.
Although prior studies have attempted to define explicit clinical criteria for the appropriateness of THA, the subjective nature of the procedure's indications requires patients to weigh the risks and benefits on the basis of their own values [ 10, 33].
Today, approval of a drug for this indication would require many more subjects with longer treatment durations, as well as a large Phase 4 cardiac outcomes study extending well beyond marketing approval.
Refractory epilepsy and dementia are the main indications requiring dedicated hippocampal imaging.
