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RA was selected to estimate the budget impact, as this indication involves the largest number of patients treated with biological agents.
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We classified each of these drug-organ system pairs as (a) whether the drug has ever been pursued for a therapeutic indication involving that organ system, (b) whether that drug has ever elicited a clinical side effect involving that organ system, and (c) whether that drug's targets have genetic phenotype associations involving that organ system (Fig. 1; see Supplementary Data 1 for full dataset).
The popularity of testing PDT for non-traditional indications involves designing animal models of non-cancer, non-infectious disease.
Although calcilytics have failed thus far as anabolic therapies for osteoporosis, they are currently being evaluated as novel therapies for new indications involving hypocalcemia and/or hypercalciuria.
We have accounted 21 mutual indications (42 out of 144 indications), involving 21 different researchers.
Many indications involve PV cells in regulating the effects of MD on visual cortical circuits.
Data on primary indications involving trauma/fracture or revision surgery (including revisions for aseptic loosening) were excluded from this analysis.
In light of the data reviewed above, PCC appears to be a versatile haemostatic agent suitable for use in indications involving multiple clotting factor deficiencies.
Although non-invasive MDCT angiography has become the method of choice for most indications involving the abdominal and visceral arteries, no general contrast injection protocol has been established to date [ 13].
This RCT involves a non-critical indication for the use of doxycycline, and the drug under investigation is well characterised and commonly used in daily practice.
The study found that the majority of patients received injections of incobotulinumtoxinA for GFL, with over two-thirds of treatment cycles involving treatment of this indication.
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