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Methotrexate is widely used in this indication in Europe.
The remarkable improvement in a child's gait following Botox injection into tight calf muscles has led to its approval for this indication in many countries.
And yet this agent will probably not be given a licence for this indication in the European Union and the USA.
We also believe AstraZeneca was expecting contribution from this indication in order to get to the Brilinta peak sales target outlined at the time of the Pfizer bid and expect the stock to underperform today on this negative news.
This is especially true of anxiolytics, but also of antidepressants, with the exception of paroxetine and venlafaxine, which are the only drugs approved in this indication in Western countries.
No controlled results are available for other oral drugs, for instance β-blockers, but they could also be considered for this indication in clinical practice.
Similar(12)
Three studies showed the superiority of low molecular weight heparins in terms of a favourable benefit risk ratio in this indication [ 22- 24] in comparison to oral anticoagulants.
Checking of the usefulness in this indication is foreseen in the ongoing large multicenter studies.
However, metoclopramide is not officially registered for this specific indication in critically ill patients.
Ineffective as an antidepressant, but noted to have pro-sexual side effects, flibanserin was trialed for this new indication in the early 2000's.
This indication is rare in young patients and the operation is usually performed in the elderly.
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