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So, this incidence has caused me to stop and ask myself and now I ask you.
This incidence has been observed in all age groups, without any differences between vaccinated and unvaccinated birth cohorts.
This incidence has been attributed to the effects of globalization, in particular the 'nutrition transition' [ 4- 9].
Although this incidence has plateaued in many developed countries, it is still increasing in many parts of the world [ 2- 4].
This incidence has remained constant during the 15 year period from 1983-1997, but an increase has been observed in the cohort of women born after 1930-1940, probably due to a lack of screening coverage [ 2].
On the other hand, the average annual incidence of JE-negative AES during the same period was 16 cases per 100,000 persons (95% CI 14.8 17.2), and this incidence has remained relatively stable since 2008.
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Although the reasons for this increase are not well understood, the practical effect of this increasing incidence has been seen in many settings, including the California state prison system.
This low incidence has been attributed either to reduced pathogenicity or its lower prevalence in soil [ 5].
This increased incidence has not been confirmed in HORIZON-RFT, the Paget trial, 54 nor the trial for prevention of PMO.
This increasing incidence has been directly linked to hepatitis C, and indirectly linked, through studies in obesity and diabetes, to non-alcoholic steatohepatitis (NASH) [ 3- 5].
This increased incidence has been associated with advances in clinical medicine, including organ transplantation, chemotherapy, antimicrobial agents, parenteral nutrition, and medical devices, all of which improve patient survival but increase the risk of infection [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com