In the future, it will be important to build upon this important proof-of-principle study by analyzing additional patients and controls, as well as additional iPSC lines from each patient.
This is important "proof of principle" that specific causes of CIMP can be identified in colorectal cancer.
"This is an important proof of principle," says Ronald Blum Ronald Blum, director of the cancer center at Beth-Israel Cancer Center in New York.
We propose this is an important proof of concept, demonstrating that bipotential tumor stem cells are essential in tumors where oncogenic ligand-receptor pairs are separated into different cell types, and suggesting that Wnt-induced molecular and fate plasticity can close paracrine loops that are usually separated into distinct cell types.
This is an important proof of concept study.
We believe that this is an important proof of principle that justifies a systematic search for other such cases.
This is an important proof of principle and shows that increasing levels of DNAJ chaperones can be beneficial in the context of the mammalian brain.
However, this provides an important proof of principle that combining inhibitors that target MLL/AF4 complex activity can be used in combination with inhibitors of important MLL/AF4 target gene products.
Recently, such an immunomodulatory peptide, an innate defence regulator IDR-1, was shown to protect mice against bacterial infections, including infections with multidrugresistant pathogens, and this provides an important proof of principle for the immunomodulatory approach.
This analysis provides an important proof of principle for genomic modifications in this important model for vertebrate biomedical research; we expect that precise genome editing in zebrafish is possible at other loci with similar efficiencies.
"This is a very important proof of principle for using specific viral inhibitors to treat hepatitis C," says hepatologist Adrian Di Bisceglie of Saint Louis University in Missouri.
