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In view of this highly differentiated somatotopic organization it is not surprising that SCN efferents are also able to differentiate between sympathetic and parasympathetic pre-autonomic neurons.
It is likely that COPI-mediated intracellular transport may be abundant in this highly differentiated secretory tissue compared with other tissues.
This highly differentiated variant of SCC is characterized by bulbous pegs of neoplastic cells that appear to push into the underlying stroma.
This highly differentiated phenotype observed in the CD8+ subset has been associated with CD57 expression in the CD45RA+ population; some of these cells have also been shown to lack expression of CD28 [ 40].
As CD8+CD28− T cells have short telomeres and fail to undergo substantial proliferation following antigenic contact, this highly differentiated T-cell subset has been attributed a state of replicative exhaustion and cellular senescence (Effros et al., 2005).
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Nevertheless, this synovial cytokine profile is consistent with the highly differentiated CD45RObrightRBdull phenotype of synovial T cells [ 4].
All of those developments are instrumental in undermining the highly differentiated educational system in Germany, with its "Facharbeiter", "Meister" and well trained engineers.
In this study, highly differentiated SH-SY5Y cells were correlated with high WWOX protein expression and low Tau S396 and S404 protein phosphorylation.
This set of highly differentiated genes was, however, not enriched for any particular functional category.
The GT4 seedcake preparations were directly applied to the stratum corneum of this air-lifted, highly differentiated culture.
In human cells, genes belonging to this family exhibit highly differentiated expression patterns, intracellular localization and function.
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