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This heterogeneity of reporting formats may influence clinical interpretation, given the differing levels of familiarity with genetic and genomic tests among ordering clinicians [ 47– 51].
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Systematic reviews of this topic have not provided practice-relevant guidance because of the generally low quality of research and the heterogeneity of reported effectiveness.
In this view, changes of experimental parameters such as target cell type (MEF versus HeLa cells), MOI, time of infection (from 1 to 24 h), effective number of intracellular bacteria and the use of exogenous adhesion systems (e.g., AFA E, E. coli afimbrial adhesin), could well account for the heterogeneity of reported results.
More than my inexperience with programming techniques, however, it was the utter heterogeneity of reporting styles that took me a while to accustom myself to.
The heterogeneity of reporting found in the current meta-analysis is not surprising.
Among the included studies, there was broad heterogeneity of reported characteristics.
Therefore, because of the remarkable heterogeneity of reported adherence rates and of methods of determination used, a comparison of the different methods appears to be of particular relevamce.
The heterogeneity of reported data may be due to the use of distinct procedures for subject selection and to the nature of the assessed population.
Only a qualitative synthesis was carried out due to the scarcity of studies, considerable design differences and heterogeneity of reported outcomes.
As demonstrated in additional file 2 there is heterogeneity of reported patient characteristics and methods for assessing and reporting these differences, which highlights the lack of standardisation in this area.
Since anaphylaxis was not amongst those conditions, an assessment of the heterogeneity and quality of reporting of outcome measures was considered useful.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com