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Although past studies confirmed this germ was linked with both of these catastrophes, much controversy existed as to whether it also caused the Justinianic Plague of the sixth to eighth centuries.
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Noteworthy, this region was linked to testicular germ cell tumours (Rapley et al, 2000) and hereditary prostate cancer (Lange et al, 1999; Peters et al, 2001), and miRNAs in the cluster were implicated in clear cell renal carcinoma (Zhou et al, 2010).
Whatever this germ was, it belonged in Building 15.
A hypothesis that fits well with the data obtained in this study is that this specificity may be linked to roles that are performed in male germ cells, but not in somatic cells or female germ cells.
Exposure to the anti-androgenic fungicide vinclozolin, the estrogenic pesticide methoxychlor, or a mixture of plastic compounds during reprogramming of the germ line has been linked with epigenetic alterations that are inherited transgenerationally even in the absence of continued exposure [ 11- 15].
This effect has been linked to altered DNA-methylation of the corticotropin-releasing factors receptor 2 in the brain and in the germ line.
This is linked to knowing thyself.
Its expression was described to be central in germ cells and SCs maturation and its reduced level has been linked to germ cells and SCs proliferation block [ 38].
In long-term cultured spermatogonia genes LRRN1 and CXADR, both of which are linked to germ cells, were upregulated.
Interestingly, substantial attrition of oocytes occurs during female embryonic germ line development; the process is linked to transposon mobilization and occurs at meiotic prophase I.
Tsx is a long non-coding RNA that has been linked to germ cell function, but interestingly mice that lack Tsx show enhanced short-term memory function (Anguera et al, 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com