This complex function underlies what is variously described as, for example, working memory, spatial (dorsal) or object (ventral) cognition, selective attention or the "central executive" [51], [53] [55] and the prediction of future reward [56].
Age-related decline of immune function underlies this critical vulnerability.
This coupled with deficient insulin secretion suggestive of deteriorating β-cell function underlies the development of GDM [17].
It is conceivable that a similar dual function underlies the essential role of BAG-1 in DALIS formation during the early phase of immune cell maturation.
Impairment of cilia and flagella function underlies a growing number of human genetic diseases.
Furthermore, since normal endothelial function underlies normal microvascular function, there is an increasing interest in endothelial function during sepsis [ 9- 12].
Further study of RECQL4 patient mutations could resolve whether such a secondary function underlies the disease phenotypes.
It may be argued that deterioration of liver function underlies the positive association between alcohol and bilirubin.
It may be that a control problem, reflecting damage to a general executive function, underlies both patterns.
These observations suggest that impaired PPAR-γ expression or function underlies unopposed fibroblast activation and progression of fibrosis in SSc.
Indeed, inhibition of RANKL/RANK function in osteoclast formation, survival, and function underlies the therapeutic efficacy of denosumab in the treatment of osteoporosis [ 24].
