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However, the C-terminal fragment of p53 was unable to influence reticular Ca2+ homeostasis and sensitivity to oxidative stress per se, indicating that this function resides in another domain of the protein.
The core function of NusG and Spt4/5 is to stimulate transcription elongation and RNAP processivity, and this function resides in the conserved NGN domain (Burova et al, 1995; Chen et al, 2009).
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But what actually matters is the function, and a large part of that function resides in the Link.
Whether this protective function resides with FAD or whether FAD was retained in the evolutionary process solely for its ability to stabilize the AidB tetramer remains to be determined.
To determine whether this additional sensory function resides among the exposed or non-exposed class of neurons, we tested osm-3 p802 osm-3 p802 all exposed cinia are defective, but non-exposed cilia are intact [12].
Imaging studies of people with attention deficits have shown a consistent pattern of below-normal activity in the brain's frontal lobes, where so-called executive function resides.
Furthermore, the regulatory function resides in the tail domain of vinculin containing the paxillin-binding site.
Dock proteins are characterized by the presence of a carboxy-terminal domain known as CZH2, where their GEF function resides.
In the 16 chromosomes of S. cerevisiae, centromeric function resides in an essential 125 bp long CEN sequence that comprises three conserved functional elements (CDEI, II, III).
The NS3 protease function resides in the N-terminal domains, which fold into a cashew-shaped structure, with a serine protease active site in a shallow cleft.
This approach to model development is in line with the current shift from focus on manipulating individual genes and pathways to the consideration that biological function resides within highly interconnected modules of molecular networks (5, 6).
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