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This focal expression of Mmp13 in the tumor core was very different from the expression of Mmp2 and Mmp14, which were found throughout the tumor stroma, including at the tumor periphery (Fig. 2 e h), and in areas with hyperplasia, grade I and grade II MIN (not shown).
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In his preface to Pragmatism (1907), James commented that the pragmatic movement was the focal expression of a number of philosophical tendencies suddenly becoming conscious of themselves and of "their combined mission".
One of the most intriguing observations in our study of fascin expression in IBD was the focal expression of fascin in regions demonstrating active tissue repair.
Ahmad et al. reported that focal expression of MMP-11 by breast carcinoma cells was attributed to epithelial-to-mesenchymal transition (EMT) [ 23].
They rather reflect the local differences within the regions and the focal expression of the mediators and enzyme activity along the femoral shaft.
In this study, we first verified the increased level of sNRP-1 in circulation and the focal expression of NRP-1 protein in a subset of cervical cancerous and precancerous patients by ELISA and IHC, respectively.
Further, TREM-1 was absent from normal/reactive synovial cell extracts, indicating a focal expression of this factor in inflamed areas of OA synovial membrane.
The predominantly focal expression of MAGE-1 suggests that this antigen might not be sufficient as a sole target for immunotherapeutic approaches.
As we have pointed out ourselves before [ 21], the TMA technique may have limitations for proteins showing focal expression such as HIF-1α when it is expressed next to small necrotic areas [ 22].
In malignant basal cell carcinoma (BCC), p65 was expressed in the epithelial nuclei and there was positive focal expression in the cytoplasm.
Focal expression of STn was seen although all the E3-STn cells expressed STn in vitro (see Supplementary Figure S1).
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