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This finding is underscored by the complete absence of Txnrd1 protein observed in brain homogenates from Txnrd1-NS null mice.
The structural and functional significance of this finding is underscored by a similar dependence on OGT of disorder found in long IDRs and mostly disordered proteins (Supplementary material, Figure S2).
The importance of this finding is underscored by earlier research demonstrating that QOL scores are themselves independent predictors of patient mortality.
This finding is underscored by the fact that phosphorylation of STAT3 is associated with markers of stability in human carotid atherosclerotic plaques.
The importance of this finding is underscored by our knowledge that insulin resistance is a very prominent and early feature of the metabolic syndrome and has consistently been associated with fetal programming in humans, regardless of whether the exposure is low birthweight, prematurity independent of low birthweight, gestational diabetes mellitus (GDM) or twin/zygosity status [ 9– 11].
This finding is underscored by our analysis of the AIL mouse data set, where five loci reach genome-wide significance when this approach is used, whereas only one locus meets genome-wide significance when all markers are used to estimate the matrices.
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This finding was underscored by the low glucose levels at 16 weeks in the LT16 group compared with age-matched controls, and at 19 weeks, the LT19 group glucose levels were not only lower than those of the LT16 group, but also significantly different from those of age-matched controls.
The functional significance of these findings is underscored by the identification of a strong positive correlation between liver docosahexaenoic acid content and cognitive status (P<0.0001).
The therapeutic importance of these findings is underscored by the remarkable success in the treatment of autoimmune pathology using medications initially developed for use in oncology and this arena is one of considerable therapeutic promise for rheumatologists.
Finally, the relevance of these findings is underscored by the fact that levels of palmitoylated CD44 were lower in primary cultures from invasive ductal carcinomas relative to non-tumour tissue, while CD44 co-localisation with a lipid raft marker was less in invasive ductal carcinoma relative to ductal carcinoma in situ cultures.
The clinical significance of these findings was underscored by two independent groups showing that high expression of IGFBP-3 in breast tumor tissue is associated with markers of aggressiveness and poor prognosis, including ER- and progesterone receptor- (PR-) negativity, high S-phase fraction, and aneuploidy [ 32, 33].
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