Furthermore, the fact that guanidine-resistant variants are readily selected during treatment despite their fitness cost suggest that, at least in this example, relying on high fitness cost to prevent the emergence of resistance is insufficient; additional factors must be at play to prevent the emergence of resistance from a single drug regimen.
Even this simplified example relies on an impressive array of biological, statistical and algorithmic expertise embedded in interacting software tools.
It does this better in some disciplines than others – the display of contemporary architecture, for example, relies too heavily on the most polished works of the most established names and so makes the subject less vital than it actually is.
Ward Melville High School in Setauket, for example, relies heavily on Stony Brook University's resources.
Exeter's endowment, for example, relies on Stephen F. Mandel, who graduated in 1974, to oversee its portfolio.
Colorado, for example, relies on state assessments of whether existing regulations are functioning properly.
Islamic law, for example, relies heavily on testimony under oath for criminal convictions.
City Harvest, for example, relies on 100 paid employees and 700 volunteers who gather surplus food and deliver it.
The United Automobile Workers, for example, relies on delegates to elect its president, while the Teamsters union uses direct elections.
