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(25,442 – 132,230) this estimate needs to viewed with caution.
This is likely due to the very low rate and stochastic nature of SNP accumulation, and indicates that this estimate needs to be used with caution.
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This estimate however needs to take into consideration non-biomineralizing secreted proteins that do not possess similarity with previously described GenBank sequences.
To reduce the noise effect, final estimate needs to be averaged over a number of samples.
Although this means these estimates need to be interpreted with caution, they probably reflect real life as in routine clinical practice this distinction is often not as clear cut: physicians will often discuss risk estimates with patients and patients will often ask physicians for advice on interpreting estimates.
This effect is likely to be compounded by the increasing frailty observed in this study, and if these trends continue this estimate may need to be revised upward.
Since our best-fit line is based on only 12 strains, it is likely that this estimate will need to be revised as additional genome sequences become available.
This information was not available to us, so an estimate needed to be made from another source.
To offset this situation, estimates need to be made based on analogy, on the study of the construction techniques, on the information collected from specialised firms and on scientific literature.
A few GOI officials admitted informally that these estimates need to be taken with caution.
The House bill covers about 200 warriors, a tenth of the estimated need.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com