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This error-free repair appears to be locally balanced with a strand biased error-prone introduction of mutations at A T sites, which is largely impaired in the absence of MutSα complexes.
Fig. 1 summarizes a model for this error-free double strand break repair pathway (based on reference [ 16]).
This error-free repair pathway may thus protect X-linked genes from (intron) deletions at transcription-induced DSBs.
Inactivation of BRCA1, BRCA2 or any other critical protein within this "BRCA pathway" due to a gene mutation should inactivate this error-free repair process.
A critical protein function lost from anywhere within this error-free repair BRCA pathway may force repair of DNA double strand breaks by lower fidelity, error prone methods.
Both branches of this pathway are error free.
To the best of our knowledge this is the fastest error free large signal modulation of any VCSEL at 85 °C.
As with any application of currently available natural language processing, this system is not error free.
Indeed, because HR repair is usually error free, this would be expected to protect genome integrity following DSB induction or replication fork collapse at such sites, which would be important in maintaining cell homeostasis.
Nevertheless, this computerized approach is not error free, and double-checking must be performed by the prescriber physician.
Therefore, the benchmark examiner is assumed to be error free; however, this person is actually no more than an experienced examiner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com