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Expression of this enzyme is regulated in response to dietary sterol levels and this regulation is coordinated with HMGCR [38].
The activity of this enzyme is regulated by the concentration of orthophosphates (the end-product) [29].
Although Glo1 is ubiquitously expressed, limited information is available on how this enzyme is regulated in human cells.
This enzyme is regulated throughout the different growth phases [14] and is involved in resistance to pH and nutritional stress conditions [15] and in oxidative stress [16].
The higher expression and activity of DDAH-1 in TR KO liver suggests that this enzyme is regulated during liver regeneration in the TR-deficient mice.
Although this enzyme is regulated by dietary fat it is currently unknown, whether iPTL is involved in TG absorption.
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For most biosynthetic pathways, the enzyme is regulated to produce a specific product from a precursor.
If the enzyme is regulated by additional factors, more parameters are added (e.g. Ki for affinity to an inhibitor; Ka for an activator).
Nevertheless, how the activity of this DNA repair enzyme is regulated remains less clear.
Future work is now needed to understand how this new role for the AID enzyme is regulated, and whether this role beneficial or harmful to the immune cells.
The first enzyme is regulated by redox cues, while PCT-BMYI is capable of hydrolysing, in addition to soluble starch, intact potato starch granules [ 43].
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