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This enzyme contributes to maintain the NADH pool by recycling NAD+ through the conversion of pyruvate to alanine when oxygen, as a terminal electron acceptor, becomes limiting [27].
This enzyme contributes to acidification of vacuolar and organelle contents.
CPA can be generated by autotaxin (ATX) under non-physiological conditions using a two-phase water/ether reaction system (Tsuda et al., 2006), but whether this enzyme contributes to the formation of CPA in blood remains an open question.
How this enzyme contributes to the functions of bacteria in the gastrointestinal tract is not known.
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The present study was undertaken to explore the P-site of human BuChE and determine whether, like AChE, aromatic side chains near the peripheral aspartate (D70) of this enzyme contribute to ligand binding.
In a mouse model of human African trypanosomiasis, the enzyme contributes to virulence of a pleomorphic strain of T. brucei [8].
It is possible that tyrosine nitration of this key enzyme contributes to enhanced intrinsic renal gluconeogenesis during hyperglycaemic states.
Among all UDP-GT inducers tested in the study, UDP-GT activity was negatively correlated with serum total and free T4 levels, supporting the hypothesis that induction of this microsomal enzyme contributes to the PCB-related reduction in circulating TH levels.
The idea that both the substrate and the enzyme contribute to catalysis (substrate assisted catalysis; SAC) is applicable to guanine nucleotide-binding proteins (G proteins).
Hydrophobic and hydrogen bonding interactions in the various subsites of the enzyme, contributing to both increase as well as decrease in selectivity of the molecules have been detailed.
Collectively, the activity of these enzymes contributes to tumour immune tolerance and immune dysregulation in a variety of disease pathologies, including cancer.
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