Sentence examples for this endpoint has from inspiring English sources

However, this endpoint has been used in an increasing number of RCTs (Fig. 3).

This endpoint has been estimated to be one of those that will require more animal use (and more money, as a consequence) to comply with REACH [5, 6].

This endpoint has been recently validated by a study which showed that six-month progression-free survival can be used as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide [27].

Use of subjective fever in the case definition may lack specificity, and has been avoided in some studies[6], but the specificity of this endpoint has not been formally calculated.

This endpoint has been commonly used in studies of antimalarial efficacy, particularly for treatments intended for severe malaria [ 40].

Clear evidence from randomized controlled trials powered on this endpoint has demonstrated that topiramate 100 mg/day or 200 mg/day is more effective than placebo in reducing the mean monthly frequency of migraines.

The complexity, length, and cost of the experiments, and the late recognition of the importance of this endpoint have resulted in a low number of available studies.

The sample size estimate was based on projected changes in aerobic walking capacity (cardiorespiratory fitness) as measured by the 400-m walk as this study endpoint has been shown to be a strong predictor of mortality, CVD and mobility limitations in older adults [ 28, 40, 41].

This type of endpoint has been used previously in clinical trials in which survival outcomes have been shown to be similar between treatment regimens; thus, a regimen that reduces the risk of toxicity is clinically relevant, particularly in the palliative setting.

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