Although most of the data supporting use of this endpoint are from studies in drug-susceptible TB, Holtz et al. [10] demonstrated a patient-level relationship between shorter time-to-culture conversion and final treatment outcome.
The AUC values for the 40 different prediction models for this endpoint ranged from 0.875 to 0.939 in the independent validation set.
The weakness of this endpoint results from the difficulty in distinguishing between tumor-related and treatment-related clinical and imaging changes, and this may make this endpoint quite unreliable, with survival potentially being the only definitive endpoint.
As a secondary data source, bioactivity is not always available, thus this method cannot be used when only chemical structures are available; furthermore, by changing the endpoint from one bioactivity source to another, clusters are likely to re-arrange.
Here, a script tag is created in which the endpoint from which data is to be received is defined as the src-attribute.
On this endpoint day, lungs from 5 mice were sampled and weighed, and homogenates thereof were desiccated for dry weight determination.
Lou Reed, the godfather of all attitudinal rock, starts his Metal Machine Trio gig from this endpoint: a clutch of guitars leaning against a wall of amplifiers, already fulfilling the event's billing as "an evening of deep noise".
It runs north from this endpoint, which is unconnected to the rest of the trunkline system, to the vicinity of Crane Park in Kalamazoo along Westnedge Avenue.
As the treatment was symptomatic, this endpoint was relevant clinically and from the patient's point of view.
This endpoint would have included patients dying from primary cardiac as well as noncardiac etiologies.
