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To Samsung, this effect is lethal.
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The reverse genetic techniques that are presently being used in C. elegans are all more likely to result in complete-loss-of-function alleles which, if the effect is lethal or detrimental, may limit the analysis that can be done.
It only stung for a moment, but the effect was lethal.
Lower temperatures decrease their scope for aerobic activity, and the added narcotic effect of Mg2+ is lethal at temperatures below ∼1°C [35].
This difference suggests that RF1 knockout creates burdens for cells due to the lack of proper termination and relatively weak missuppression of UAGs by near-cognate tRNAs, yet the effect is not lethal as perceived before.
Although the exact mechanism responsible for this lethal effect is not clear at present, studies have suggested the presence of GNPs at the diseased sites.
Both duplications showed similar dosage effects and were lethal as homozygotes.
At the organismal population level, most mutations have either no or negligible phenotypic effects or are lethal (reviewed in [ 50]).
"Whether this sub-lethal effect is actually therapeutic to honey bees is a very interesting question, and one that I'd like to investigate".
Apparently, the lethal effect is due to the inability of GNPs to stimulate a strong immune response, which allows them to diffuse freely into cells.
Second, as the lethal effect is very specific, it presumably has a simple genetic basis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com