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In agreement with a tumor suppressor function, HD-PTP expression inhibits ras-mediated transformation of NIH-3T3 cells; this effect is abrogated by deletion of its PTP domain as well as by incorporation of a C/S mutation suggesting that HD-PTP catalytic activity regulates this function [4].
This effect is abrogated by dexamethasone.
Moreover, this effect is abrogated by the endometrial cancer-associated SPOP mutations.
This effect is abrogated by VDAC2 knockdown (MOVDAC2, 25.3 ± 5.5% embryos, n = 97).
GU81 increases macrophage infiltration as a single-agent [ 10], however, this effect is abrogated when GU81 combined with doxorubicin.
Epidermal growth factor was able to further activate the tyrosine phosphorylation of ErbB receptors, and this effect is abrogated by the 2 h treatment with GW2974 (Bands around 175 kDa correspond to ErbB receptors in Figure 2B).
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FIT stimulation of H9C2 cells also caused a time-dependent phosphorylation of STAT3, Akt, and GSK-3beta, and this effect was abrogated by AG-490.
The specificity of SPLINTER improved with higher coverage, whereas VarScan2 yielded more false positive results at high coverage levels, although this effect was abrogated by removing low-quality reads before variant identification.
At 5 minutes of reperfusion, both MOR and BW increased P-GSKbeta at Ser9 in the ischemic zone compared with vehicle (181+/-20, 178+/-15 versus 75+/-17 75+/-17pectively; P<0.05), anDU,his effect was abrespectivelyrior administration of wortmannin or raP<0.05n in MOR-treandd rathis
After nociceptive stimulation of the first trigeminal branch with intranasal capsaicin (as a model of TRPV1-mediated craniofacial pain with central sensitization), alternating application of CO2 reduced pain ratings only minimally compared to a sham paradigm with air, but this effect was abrogated during continuous insufflation of CO2.
This effect was abrogated by a co-application of the MEK inhibitor, PD98059 (30 µM), or the phosphatidyilinositol-3-kinase (PI-3-K) inhibitor, LY294002 (30 µM) (Fig. 6C).
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