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This dosing is similar to a rEpo dose of 60 000–100 000 IU dose−1 in humans, as referenced in previous work (Blackwell et al, 2003).
This dosing is for individuals who weigh 50 70 kg and should be scaled up or down for those who are outside this weight range.
Notably, this dosing is in contrast to 10 mg twice per day utilized in the pivotal trials reported by Reisberg and colleagues and Tariot and colleagues.
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This dosing was based on a phase 1 study where this dosing combination was used (Patel et al, 2013).
For relativistic electrons this dose is about 0.032 Gy.
However, this dose is insufficient to normalize glutamine plasma concentration.
This dose is to be considered an optimum dose compared with other doses.
This dose is 2.5 mg for frovatriptan [31] and 10 mg for rizatriptan [32].
This dose is likely to be above the threshold of destruction of ovarian cancer micrometastasis.
Based on the known radiosensitizing effect of Topotecan, this dose is recommended for phase II testing.
From the results of previous studies, this dose is high enough to treat pathological tissues.
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