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The phrase "this differs dramatically" is correct and usable in written English.
You can use it to highlight a significant difference between two or more subjects or ideas. Example: "The results of the two studies show that this differs dramatically in terms of effectiveness."
Exact(3)
Only 15% of the patients were sputum smear-positive; this differs dramatically from adults, among whom approximately half of notified TB cases have sputum smear-positive PTB.
This differs dramatically from canonical MOB glomeruli, which are targeted by OSNs expressing the same OR and thus receive homogeneous odor input [15], [17], [26], [34], [35] (Fig. 3).
This differs dramatically from the LOE proposed by Colozza et al. [ 24] who suggested a level III or even IV.
Similar(56)
They also show that the AT to GC bias for polymorphism in this region differs dramatically from that for substitutions.
The rapid recovery demonstrated in this study differs dramatically from the situation in subarctic Canada where geese have pushed the ecosystem to an alternate stable state dominated by exposed sediment (Jefferies et al. 2006) and the removal of the herbivore has been demonstrated not to be sufficient to restore the vegetation (Handa and Jefferies 2000).
The movement of large groups of residents into temporary housing has created new communities whose makeup differs dramatically from the pre-disaster days.
Palm trees along the lake thrive in the town's mild microclimate, which differs dramatically from the colder temperatures in the surrounding mountains.
In contrast, the performance of the reference priors differs dramatically from that of the π U prior.
Though brewed by Guinness, Harp differs dramatically from its parent.
Our world differs dramatically from the biblical worlds in everything from technology to politics to the organization of family life.
Under light-limited conditions (Stage 1), the picture differs dramatically depending on the model.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com